According to Abram, this “cryopreservation” method has revolutionized the potential of IVF, by giving women “greater control over their fertility years.”
In response TMRW, which launched commercially in February and has raised $60 million in funding, has created what it claims is the world’s first automated platform for the management, identification and storage of frozen eggs and embryos.
TMRW’s system embeds radio frequency identification (RFID) chips into the vials used to store eggs and embryos. This allow the samples to be identified and tracked with complete accuracy, avoiding any possible mix ups, says Abram.
The vials are stored in liquid nitrogen in a “cryo-robot” tank equipped with sensors that detect small changes, such as variations in temperature and electricity consumption, which might signal a problem. Potential mishaps are identified before the point that the frozen tissues are affected, says the company, while patient details are kept secure using military-grade data encryption.
Peace of mind
Dr. William Schoolcraft, founder and medical director of CCRM, a fertility and IVF company with 25 clinics across the United States, has been trialing TMRW’s technology for the last six months, using donated specimens. He says the tests — designed to assess if tissue survival was “at least as good as our existing technology” — were successful.
The responsibility of running a fertility clinic is a bit like “flying an airplane,” he says. “It’s great as long as it’s great, but when things go bad, it’s a full-on disaster.”
Schoolcraft says CCRM’s current security measures, which are typical of many fertility clinics, involve visual inspections of storage tanks to look for indicators of liquid nitrogen leaks such as condensation and frost accumulation. In addition, if a tank’s temperature rises significantly, threatening the stored tissues, an alarm triggers automatic phone calls to different members of staff, until someone responds.
The TMRW system appeals because it offers constant, automated monitoring, with the ability to detect potential tank failures earlier than humans can, as well as extra levels of safety when it comes to identifying and tracking of tissues, says Schoolcraft. With CCRM planning to implement the platform in all its clinics by the end of the year, he hopes he will no longer be kept “awake at night” with worry.
A clinician places a container of eggs and embryos in TMRW’s cryo-robot.
Abram says TMRW operates a subscription revenue model, providing their hardware to clinics without cost and charging a fee per patient per month. Patients will need to pay an extra $25 to $30 monthly — “a reasonable cost” to avoid the potential disaster of eggs or embryos being lost, says Schoolcraft.
TMRW says its technology is already up and running in two US clinics and anticipates it will be operating in 30 locations by the end of the year. The company is pursuing regulatory approval in the United Kingdom and Europe with plans to open a showroom in London later this year and expand to Europe in 2022, says Abram.